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Polygence Scholar2026
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Saya Toth

Class of 2027

About

Projects

  • "analysis on public H3K27M diffuse midline glioma (DMG) scRNA-seq data, stratified by anatomical location" with mentor Mathias (Sept. 24, 2026)

Project Portfolio

analysis on public H3K27M diffuse midline glioma (DMG) scRNA-seq data, stratified by anatomical location

Started June 4, 2026

Abstract or project description

  1. Research question Do tumor–microglia cell–cell communication networks differ between pontine and thalamic H3K27M-mutant diffuse midline gliomas (DMGs) in public scRNA-seq data?

  2. Hypothesis (directional) H1: At least one ligand–receptor (L-R) pair in the malignant → microglia direction has a different per-sample communication probability between pontine and thalamic H3K27M DMG samples.

H0: No L-R pair differs between locations after multiple-testing correction.